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Polynucleotide treatments

Polynucleotides are an advanced injectable skin rejuvenation treatment, which trigger your body’s own healing mechanisms to restore skin health. Polynucleotide serums are safe, ultrapure and deliver amazing results.

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TREATMENT SUMMARY

Procedure time
30 mins
Recovery time
24 - 48 hours
Duration of results
3 months
Sessions required
2 sessions 2-4 weeks apart Top up after 12 months
Treatment areas
Anywhere
Discomfort level
Minimal

Why use Polynucleotides?

A new concept in regenerative medicine at Dr MediSpa

As advancements in skin rejuvenation within aesthetic medicine continue to innovate and improve, new and exciting treatments emerge, with the power to rejuvenate, heal and revitalise the skin, from within.
At DrMedispa in London and Essex, we don’t believe in sitting still when it comes to researching and introducing revolutionary treatments and remain ahead of the game with our cosmetic enhancement offerings, for youthful, resilient and healthy-looking skin.
One such breakthrough in injectable skincare is Polynucleotides, a new concept in regenerative medicine which, when injected promote cell turnover, improve skin hydration and elasticity, heal damage caused by UV rays and improve photoaging and acne scarring. At Dr Medispa we offer Plenyhage, Juvenus and Nucleofill Polynucleotides products.
We are seeing impressive results with Polynucleotides for skin rejuvenation, scar correction and hair loss.

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Frequently Asked Questions

What are Polynucleotides?

Polynucleotides (PDRNs) are ultrapure DNA fractions, which stimulate skin rejuvenation at the cellular level. They They also have an anti-free radical action, scavenging damaging OH hydroxyl radicals, which can accumulate as a result of cell damage from external pollution, stress and UV rays.

Once Polynucleotides have been filtered and purified, the DNA fractions within when expertly injected in to the mid dermis, initiate your body’s own natural fibroblast production which results in a thicker, healthier epidermis (up to 52% in 23 days) and increased collagen production (up to 47% in 23 days). Inflammation is reduced and a more youthful volume and skin hydration is restored.

How can Polynucleotides be used?

Due to their restorative action, Polynucleotides can treat a variety of skin concerns, including:

  • Acne and acne scarring
  • General signs of ageing (fine and deeper lines and wrinkles)
  • Trauma or surgical scarring
  • Dehydrated skin
  • Sagging skin losing elasticity
  • Rosacea
  • Hair loss (alopecia)
  • Hyperpigmentation and sun damage
  • Stretch marks

Areas that can be treated with Polynucleotides include the entire face and neck, décolleté, the eye area (they offer an alternative to dermal filler tear trough treatment), abdomen, arms and knees.

As a natural, regenerative injectable, Polynucleotides can also be used safely in conjunction with other injectables and skin treatments. These typically include laser resurfacing, radiofrequency, dermal fillers, signature facials, anti-wrinkle treatments and ultrasound treatments.

Are Polynucleotides the same as dermal fillers?

No – dermal fillers are made from hyaluronic acid, which fills an area and attracts water, whereas injectable Polynucleotide serum doesn’t fill the space. It does have a moisturising effect by attracting water, but also acts as an antioxidant and an internal messenger, signalling to the dermis to grow new skin cells.

What is the difference between Polynucleotide treatment and other skin boosters such as Profhilo?

Polynucleotides represent the next generation of skin boosters. They offer the same or better results as Profhilo (made from Hyaluronic Acid), but are made from DNA fragments which stimulate fibroblasts in the skin. PDRNs also have an anti-inflammatory effect, removing free radicals from the dermis.

Profhilo is a better hydrator of the skin than Polynucleotides are, and gives a dewy glow to the skin. Polynucleotide treatments like Juvenus, Nucleofill and Plenyhage offer a similar effect and are a great option in areas such as the under-eye, where too much water attraction isn’t wanted.

Am I suitable for a treatment with Polynucleotides?

At Dr Medispa, we always advise that you attend a no obligation consultation, before any treatment can be agreed upon. We will examine your skin and discuss with you, your options for this treatment and where we believe it will be most beneficial to inject, whether this is a full-face rejuvenation treatment or a targeted procedure. We will also check your medical history to ensure that the treatment will be safe for you to undergo. Once this initial consultation is complete and you are happy to proceed, you can book in for your first session.

What happens during a treatment using Polynucleotides?

After completing some standard consent forms, you will be made comfortable in one of our treatment rooms. Your skin will be cleansed thoroughly and a topical anaesthetic, applied, for maximum comfort during the treatment. Once this has sufficiently numbed the treatment area, small injections of the Polynucleotides will be made at various points, where we feel that the Polynucleotides will benefit your skin concern. Once the treatment is complete, you can return to your daily activities, adhering to any aftercare advice, your Dr Medispa practitioner offers.

Are there any side effects / risks with Polynucleotides?

Unlike with some traditional dermal filler treatments, there is no risk of occlusion, permanent lumping, blindness or other related complications with Polynucleotides. The product is extremely pure and to date, there have been no adverse reactions to the product.

Is there any downtime following a treatment with Polynucleotides?

There is no clinical downtime with this treatment. However, as with any injectable procedure, you might experience some slight bruising, swelling or tenderness at the injection sites, but this should subside within a few days.

How many treatment sessions will I need?

This does depend on your individual skin concerns, however, we will usually recommend 4 treatment sessions, 4 weeks apart for optimum results and then a maintenance session once every 6 to 12 months. Results should continue to improve in the months that follow your initial treatment sessions.

Reviews

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Debra Wilkinson profile picture
Debra Wilkinson
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I am halfway through my treatment programme but so far very happy with the results and service. I have made a big financial commitment but after initial consultations, feel well informed and believe my expectations have been managed appropriately. Everyone in the salon is very friendly and helpful and I feel comfortable and well looked after when I'm there. Ellie is very knowledgeable and thorough. Would highly recommend.
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Janan Shakir profile picture
Janan Shakir
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Absolutely love this clinic. Lucia is a star. Wouldn’t go anywhere else
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Suela Kordhaku profile picture
Suela Kordhaku
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The only place I trust with my face. I’m quite particular and have a medical background, so I don’t say that lightly. Everything is done properly, with care and precision, never rushed. Ellie is incredibly thorough and consistent, and Olaya has genuinely helped me get my confidence and my skin back. Professional, honest, and results-driven. I wouldn’t go anywhere else.
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Carina Bartle profile picture
Carina Bartle
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I have been seeing Dr Somji regularly and exclusively for 10 years (usually every 3/5 months) and have always trusted his expertise I can honestly say he is the best. His clinic team also are fantastic. Last week I had a fire and ice facial with Mariana, it left me glowing and I also had a nice skin care lesson from Mariana, she was very knowledgable and it is certainly a treatment I would book again. Thank you to all the team
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Annette Machon profile picture
Annette Machon
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I’ve always felt very comfortable visiting DrMediSpa. Dr Somji is extremely knowledgeable and professional and the staff are welcoming, friendly, kind and courteous. It’s always obvious that the clinic is a lovely working environment for the staff and would recommend the clinic 100%. I wouldn’t dream of going anywhere else
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Milan Shah profile picture
Milan Shah
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Great experience with Dr Munirs guidance, Dr Bhavik Shahs expertise and Claudia who performed the treatment for Dye IPL and Ipixel. The journey was carefully thought out and was a lot less painful than I thought. Thank you all at Dr Medispa!
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Maria Goodspeed profile picture
Maria Goodspeed
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I always enjoy visiting Dr MediSpa! The staff are incredibly friendly and welcoming, making every appointment a great experience. They take the time to understand my needs and always recommend the best treatments. I trust their expertise completely and always leave feeling refreshed and confident. Highly recommend!
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Accounting and Tax Academy by Tony D
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Fantastic :-) I visited Dr Somji's mid 2025, and through a robust, transparent and consultative process, received treatment for my alopecia. After approximately 5 months from my first round of treatment, there are visible signs of my hair growing back A big shout out to Amz Dhanjal at the front desk for co-ordinating (and buying me a cup of tea from Gails)
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LEILY BANAN profile picture
LEILY BANAN
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I see Dr somji and Elli today. I loveee Somji and his lovey wife Henal I've been coming to the clinic for 6-7 years now and super happy with every visit and results. My sister comes here too and alway so happy. I'm in the industry myself and wouldn't go anywhere else highly recommend
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Emily profile picture
Emily
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I am very impressed with this Clinic. I am so happy with my Lip filler treatments from the very talented and artistic injector Dr Somji, who provided me with NATURAL results! He is very thorough, and won’t do any treatments he doesn’t think are necessary, he actually persuaded me to have less! During the consultation I was educated on all the risks, pros and cons, and measured my facial proportions to work out exactly what was best to suit my face naturally. His theory is ‘less is more’ and I completely agree! I went in thinking I needed jawline filler, lip filler, cheek filler and Botox which is what I’ve been told by other places, being ‘sold too’, in fact all I needed was a touch of lip and chin filler to balance my symmetry and this was absolutely perfect! He’s a master at the Cannula method, I felt minimal discomfort, had 0 bruising because the tip is blunt and my anxiety of injectables is now much less as I now know this is the safest method. I couldn’t recommend Dr Somji any more, professional, patient, understanding, safe and a master Injector! The Drs assistant Elli was very sweet too making sure I felt comfortable through out, embarrassingly held my hand to calm my nerves which I might add really helped! 5 stars!!!!

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Why choose Dr Medispa

24/7 Doctor care after your treatment
Appointments to suit you including evenings and weekends
Registered with the Care Quality Commission (CQC)
Full member of the British College of Aesthetic Medicine (BCAM)
Team of highly-qualified doctors
Range of payment options available

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