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Polynucleotide treatments

Polynucleotides are an advanced injectable skin rejuvenation treatment, which trigger your body’s own healing mechanisms to restore skin health. Polynucleotide serums are safe, ultrapure and deliver amazing results.

A new concept in regenerative medicine

As advancements in skin rejuvenation within aesthetic medicine continue to innovate and improve, new and exciting treatments emerge, with the power to rejuvenate, heal and revitalise the skin, from within.

At DrMedispa in London and Essex, we don’t believe in sitting still when it comes to researching and introducing revolutionary treatments and remain ahead of the game with our cosmetic enhancement offerings, for youthful, resilient and healthy-looking skin. One such breakthrough in injectable skincare is Polynucleotides, a new concept in regenerative medicine which, when injected promote cell turnover, improve skin hydration and elasticity, heal damage caused by UV rays and improve photoaging and acne scarring. At Dr Medispa we offer Plenyhage, Juvenus and Nucleofill Polynucleotides products.
We are seeing impressive results with Polynucleotides for skin rejuvenation, scar correction and hair loss.

What are Polynucleotides?

Polynucleotides (PDRNs) are ultrapure DNA fractions, which stimulate skin rejuvenation at the cellular level. They They also have an anti-free radical action, scavenging damaging OH hydroxyl radicals, which can accumulate as a result of cell damage from external pollution, stress and UV rays.

Once Polynucleotides have been filtered and purified, the DNA fractions within when expertly injected in to the mid dermis, initiate your body’s own natural fibroblast production which results in a thicker, healthier epidermis (up to 52% in 23 days) and increased collagen production (up to 47% in 23 days). Inflammation is reduced and a more youthful volume and skin hydration is restored.

Are Polynucleotides the same as dermal fillers?

No – dermal fillers are made from hyaluronic acid, which fills an area and attracts water, whereas injectable Polynucleotide serum doesn’t fill the space. It does have a moisturising effect by attracting water, but also acts as an antioxidant and an internal messenger, signalling to the dermis to grow new skin cells.

What can Polynucleotides be used for?

Due to their restorative action, Polynucleotides can treat a variety of skin concerns, including:

  • Acne and acne scarring
  • General signs of ageing (fine and deeper lines and wrinkles)
  • Trauma or surgical scarring
  • Dehydrated skin
  • Sagging skin losing elasticity
  • Rosacea
  • Hair loss (alopecia)
  • Hyperpigmentation and sun damage
  • Stretch marks

Areas that can be treated with Polynucleotides include the entire face and neck, décolleté, the eye area (they offer an alternative to dermal filler tear trough treatment), abdomen, arms and knees.

As a natural, regenerative injectable, Polynucleotides can also be used safely in conjunction with other injectables and skin treatments. These typically include laser resurfacing, radiofrequency, dermal fillers, signature facials, anti-wrinkle treatments and ultrasound treatments.

What is the difference between Polynucleotide treatment and other skin boosters such as Profhilo?

Polynucleotides represent the next generation of skin boosters. They offer the same or better results as Profhilo (made from Hyaluronic Acid), but are made from DNA fragments which stimulate fibroblasts in the skin. PDRNs also have an anti-inflammatory effect, removing free radicals from the dermis.

Profhilo is a better hydrator of the skin than Polynucleotides are, and gives a dewy glow to the skin. Polynucleotide treatments like Juvenus, Nucleofill and Plenyhage offer a similar effect and are a great option in areas such as the under-eye, where too much water attraction isn’t wanted.

Freqently asked questions

Am I suitable for a treatment with Polynucleotides?

At Dr Medispa, we always advise that you attend a no obligation consultation, before any treatment can be agreed upon. We will examine your skin and discuss with you, your options for this treatment and where we believe it will be most beneficial to inject, whether this is a full-face rejuvenation treatment or a targeted procedure. We will also check your medical history to ensure that the treatment will be safe for you to undergo. Once this initial consultation is complete and you are happy to proceed, you can book in for your first session.

What happens during a treatment using Polynucleotides?

After completing some standard consent forms, you will be made comfortable in one of our treatment rooms. Your skin will be cleansed thoroughly and a topical anaesthetic, applied, for maximum comfort during the treatment. Once this has sufficiently numbed the treatment area, small injections of the Polynucleotides will be made at various points, where we feel that the Polynucleotides will benefit your skin concern. Once the treatment is complete, you can return to your daily activities, adhering to any aftercare advice, your Dr Medispa practitioner offers.

Are there any side effects / risks with Polynucleotides?

Unlike with some traditional dermal filler treatments, there is no risk of occlusion, permanent lumping, blindness or other related complications with Polynucleotides. The product is extremely pure and to date, there have been no adverse reactions to the product.

Is there any downtime following a treatment with Polynucleotides?

There is no clinical downtime with this treatment. However, as with any injectable procedure, you might experience some slight bruising, swelling or tenderness at the injection sites, but this should subside within a few days.

How many treatment sessions will I need?

This does depend on your individual skin concerns, however, we will usually recommend 4 treatment sessions, 4 weeks apart for optimum results and then a maintenance session once every 6 to 12 months. Results should continue to improve in the months that follow your initial treatment sessions.



For more information about Polynucleotide treatments, or to book your consultation with one of our specialists, please contact us at Dr MediSpa.

+44 (0)20 8418 0362

Or complete the form below

Why choose Dr Medispa

24/7 Doctor care after your treatment

Any follow up appointments included in the price

Registered with the Care Quality Commission (CQC)

Full member of the British College of Aesthetic Medicine (BCAM)

Range of payment options available

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